Dysfunction of this protein results in stromal edema, disruption of collagen fibrils, and thickening of the Descemet’s membrane due to abnormal secretion of the endothelium culminating in corneal opacification. Mutations of SLC4A11 in CHED most commonly result in a truncated BTR1 protein that is unable to reach the cellular membrane and perform appropriately. SLC4A11 codes for a transmembrane protein that acts as a bicarbonate transporter, actively countering the osmotic gradient by pumping fluid from the stroma into the aqueous humor. The CHED mutation is due to an affected gene, SLC4A11, on chromosome 20p13. Separate classifications no longer exist, and CHED2 is now recognized as simply CHED, an autosomal recessive, nonprogressive disease with corneal opacification in the perinatal period. CHED1 is extremely rare, only found in five family pedigrees, and was later re-classified as a form of posterior polymorphous corneal dystrophy (PPCD) after clinical, histopathological, and electron microscopy showed more consistency with PPCD.
#Bookshelf 2 full#
That’s why we have a wide selection of stylish lamp tables to help your living space reach its full potential.In the recent past, congenital hereditary endothelial dystrophy was classified in either of two categories: Autosomal dominant, progressive (CHED1), and Autosomal recessive, nonprogressive (CHED2). Once you have a bookcase to hold your favourite novels and a comfortable sofa on which to relax, you will also need somewhere to put a lamp by which to read, or somewhere to place the book when you are ready to rest your eyes.
Many of our shelving units and bookcases are also part of stylish furniture collections, making them a great option if you want to revamp your living room completely. From contemporary steel and aluminium shelving units to traditional wood and distressed oak bookshelves, we'll have something to match your interior. We have a wide range of shelving units to suit all styles, as well. Then there’s the Timothy Oulton Axel Bookcase, which also uses reclaimed wood and metal to prove that it’s possible to marry graceful design with an environmental conscience.īut bookcases aren’t the only way to store books and other ornaments in your home. The Facet 3 Door Open Bookcase combines an open design with cupboard doors for hidden storage, while mid-century modern style comes courtesy of its geometric patterning. The Santerno, with its sleek shapes, ultra modern design and high gloss finish wouldn’t look out of place in a modern art museum, as well as serving as a practical bookcase.
We also boast a number of superb designer brands, such as Ercol and Tonelli. For something just as big but a little more contemporary, consider the artistic Riva 1920 Freedom Project 4 Bookcase, with an elegant, backless design that looks just as good displaying ornaments as it does housing books. It will complement a host of different sofas beautifully.
This piece of furniture is perfect for urban homes that require lots of storage, but also want a hint of vintage style about their living rooms. Speaking of industrial, one of our grandest, boldest bookcases is the Biblio Industrial Cabinet, which is made of oak and galvanised steel. Or you can opt for a more modern look with the clean and contemporary Halmstad bookcase, in concrete and walnut. Although quirkily designed, it remains versatile, subtle and warm, blending well with a variety of living room furniture without stealing focus. Championing reclaimed materials does not mean you must be limited to one style of bookcase, though, as we also have the Verberie wood boat bookcase.
.jpg "bookshelf 2")
These beautiful bookcases are especially popular because they are made from reclaimed wood, promoting an eco-friendly and sustainable philosophy. From the classical Villiers bookcase which will lend a rustic feel to your living or reading space, to the industrial Golbourne bookshelf of metal and pine. The range of stylish bookcases from Barker and Stonehouse has something for everyone, whether you’re an avid reader with hundreds of books or simply wish to display decorative accessories and photographs.Īt Barker and Stonehouse, we pride ourselves on our collection of bookcases, in which you’ll find the perfect piece for your home. Make a statement about your interests and lifestyle by showcasing your favourite items in a way that is totally you. Not only do they act as storage, but they also allow you to express yourself. Bookcases are an important piece of furniture in any home.
0 kommentar(er)
